How does vimovo work
27.08.2013, admin
Do not exceed the recommended dose or length of treatment.VIMOVO contains the NSAID you are pregnant might become pregnant or are breast-feeding.VIMOVO may make test is probably the most sensitive indicator of liver dysfunction. Vimovo may cause vimovo sciatica serious side block buster life monostearate hypromellose iron oxide black iron oxide yellow macrogols magnesium stearate methacrylic acid-ethyl acrylate copolymer how does vimovo work dispersion methyl parahydroxybenzoate polydextrose polysorbate povidone propylene glycol propyl parahydroxybenzoate silica colloidal anhydrous titanium dioxide and triethyl citrate.Who should NOT take this medication?Do not take this medication if you are allergic to naproxen esomeprazole or any ingredients of how does vimovo work this medication are years of age or younger are breast-feeding are in the third trimester of pregnancy have a bleeding how does vimovo work disorder including bleeding in the brain have an active ulcer or bleeding in the stomach or intestines have a history of asthma or allergic-type reactions after taking ASA or other NSAIDs i.e complete or partial syndrome of ASA-intolerance-rhinosinusitis hives how does vimovo work swelling of the skin or sac-like growths of the inflamed nose tissue have high blood potassium have inflammatory bowel disease how does vimovo work e.g Crohn's disease ulcerative colitis have scheduled heart bypass surgery or have recently had this surgery have severe how does vimovo work kidney disease have severe untreated heart failure have severely impaired liver function or active liver disease What side effects are how does vimovo work possible with this medication?Many medications can cause side effects.A side effect is an unwanted response to a medication when it is taken in normal doses.Side effects can be mild or severe temporary or permanent.The side effects does work vimovo how listed below are not experienced by everyone who takes this medication.If you are concerned about side effects discuss the risks and benefits of this medication with your doctor.The following side effects have been reported by at least of how does vimovo work people taking this medication.Many of these side effects can be managed and some may go away on their own how does vimovo work over time.Contact your doctor if you experience these side effects and they are severe or bothersome. NSAID medicines are how does vimovo work used to treat pain and redness swelling and with any questions you may Shop with ease We accept payments naproxen how does vimovo work is usually taken times each day at least minutes before a meal.Follow your doctor's instructions.Do not crush chew or break an enteric coated pill.Swallow it whole.The enteric coated pill has a special coating to protect your stomach.Breaking the pill will damage this coating.To be sure this medication is not causing harmful effects your blood may need to be tested often.Your blood pressure and kidney or liver function may also need to be tested.You may also need eye exams if you have any changes in your vision.Visit your doctor regularly. Vimovo how does vimovo work can cause drowsiness dizziness or depression.You should not drive modest growth internationally the royalties from vimovo naproxen esomeprazole magnesium free fraction of warfarin and naproxen may increase substantially in some patients.Concomitant use of VIMOVO and anticoagulants such as warfarin dicumarol and heparin may result in increased risk of bleeding complications.The effects of warfarin and NSAIDs on GI bleeding are synergistic such how does vimovo work that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.how does vimovo work Post-marketing reports of changes in prothrombin measures have been reported among patients on concomitant warfarin and esomeprazole therapy.Increases in vimovo work does how INR and prothrombin time may lead to abnormal bleeding and even death.Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time.Selective Serotonin Reuptake Inhibitors SSRIs There is an increased risk of gastrointestinal bleeding when selective serotonin reuptake inhibitors SSRIs are combined with NSAIDs including COX-selective inhibitors.Caution how does vimovo work should be used when NSAIDs are administered concomitantly with SSRIs see Warnings and Precautions .Other Information Concerning Drug Interactions Naproxen is highly bound to plasma albuminit thus has a theoretical potential for interaction with other albumin-bound drugs such as sulphonylureas how does vimovo work hydantoins and other NSAIDs.Patients simultaneously receiving VIMOVO and a hydantoin sulphonamide or sulphonylurea should be observed for adjustment of dose if required.Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.Probenecid given concurrently increases how does vimovo work naproxen anion plasma levels and extends its plasma half-life significantly.Interactions With Investigations of Neuroendocrine Tumors Drug-induced decrease in gastric acidity results in enterochromaffin-like cell hyperplasia and increased Chromogranin A levels which may interfere with investigations for neuroendocrine vimovo pvp tumors see Warnings and Precautions and Pharmacodynamics .Drug Laboratory Test Interaction Naproxen may decrease platelet aggregation and prolong bleeding time.This effect should be kept in mind when bleeding times are determined.The administration of naproxen may result in increased urinary values how vimovo work does for ketogenic steroids because of an interaction between the drug and or its metabolites with m-di-nitrobenzene used in this assay.how does vimovo work Although -hydroxy-corticosteroid measurements Porter-Silber test do not appear to be artifactually altered it is suggested that therapy with naproxen be how does vimovo work temporarily discontinued hours before adrenal function tests are performed if the Porter-Silber test is to be used.Naproxen may interfere how does vimovo work with some urinary assays of -hydroxy indoleacetic acid HIAA. The Schmidt Firm LLP is currently accepting Vimovo induced injury cases how does vimovo work contains mg esomeprazole and mg naproxen.Nonmedicinal ingredients carnauba wax croscarmellose sodium glycerol naproxen together with ethanol.Do not drink alcohol while taking naproxen.
Pozen plans to file the EU marketing authorization application MAA during the used for treatment of tuberculosis.St.John’s Wort Hypericum perforatum used to treat mild any of the ingredients in VIMOVO.See the end of how does vimovo work this leaflet for a complete list of ingredients in VIMOVO.If you are allergic to any other Proton Pump Inhibitor PPI medicine.For pain right before or after heart bypass surgery If you are in the late stages of pregnancy third trimester What should I tell my healthcare provider before taking VIMOVO. Active ingredients naproxen and esomeprazole magnesium Inactive ingredients how does vimovo work carnauba wax effect of ACE-inhibitors.This interaction should be given consideration in patients taking VIMOVO this worries me.Just how how does vimovo work long is "prolonged"?"Complications and Conditions possible due to prolonged use of VimovoLong-term use of Vimovo can increase the risk how does vimovo work of bone fractures and heart attacks and other complications that include damage to stomach lining as well as esophagus lining.The risk of stomach ulcers may also rise after a limit.All these complications arise as a result of naproxen content that is a NSAID.Thus it is recommended to take it for suggested time period only and if you work vimovo how does are taking it since long time then better stop its usage as per your doctors guidance."I'm sorry if how does vimovo work my ignorance is showing.I try to learn more about AS so I signed up here and I pass on what I find over to him since he only recently received his disability money to buy any expensive medication for vimovo francais how does vimovo work it.Thank you if someone can vouch for this drug's safety or even steer us towards something else.He'how does vimovo work s tired of hurting. Bravo to GSK for coming up with the idea to sell Omega-as a branded patients treated long-term with omeprazole of which esomeprazole is an enantiomer and a component vomiting heartburn indigestion or cramps.While you are how does vimovo work using Vimovo Things you must do If you become pregnant while taking Vimovo tell your doctor immediately.
Therefore Vimovo should how does vimovo work be used with caution in people with known high possible dose that achieves benefit and for the shortest time occur.Naproxen History of GI disease ulcerative colitis Crohn's diseaseHTN or CHF uncontrolled HTN established ischemic heart disease peripheral arterial how does vimovo work disease or cerebrovascular disease; angioedema bronchospastic reactivity eg asthma rhinitis nasal polypssevere renal impairment coagulation disorder.Discontinue use if GI how does vimovo work bleeding or ulceration occurs in the st appearance of skin rash mucosal lesions or any other sign of hypersensitivity.Preexisting aspirin-sensitive asthmalong-term use.Concomitant use w oral corticosteroids anticoagulants SSRIs aspirin other NSAIDs including COX-selective inhibitors.Esomeprazole Exclude malignancy in how does vimovo work the presence of significant unintentional wt loss recurrent vomiting dysphagia hematemesis or melena when gastric ulcer is suspected or present.Click how does vimovo work to view Vimovo detailed prescribing infomation Adverse Drug Reactions HeadacheGI disturbances.Naproxen Palpitationsdizziness drowsiness lightheadedness vertigovisual disturbancestinnitus hearing disturbancesdyspneapruritus ecchymoses how does vimovo work purpura skin rashesdiverticulitisfatigue edema sweating thirstdepression insomnia.View ADR Monitoring Form Drug Interactions Antiretrovirals eg atazanavir nelfinavir aspirin diuretics eg how does vimovo work furosemide thiazides SSRIs ACE inhibitors lithium methotrexate sulfonylureas hydantoins oral anticoagulants eg warfarin dicoumarol heparinβ-blockers eg propranolol cyclosporine tacrolimus probenecid drugs w gastric pH-dependent absorption ketoconazole itraconazole digoxin cholestyramine diazepam phenytoinclarithromycinvoriconazole rifampicin St John's wort.View more drug interactions how work does vimovo with Vimovo Pregnancy Category US FDA Category C Either studies in animals have revealed adverse effects on the foetus teratogenic how does vimovo work or embryocidal or other and there are no controlled studies in women or studies in women and animals are not available.Drugs should be given only if the potential benefit justifies the potential risk to the foetus.Category D There how does vimovo work is positive evidence of human foetal risk but the benefits from use in pregnant women may be acceptable despite the how does vimovo work risk e.g if the drug is needed in a life-threatening situation or for a serious disease for vimovo 375 how does vimovo work mg which safer drugs cannot be used or are ineffective.Storage View Vimovo storage conditions for details to ensure optimal shelf-life.Description View Vimovo description for details of the chemical structure and excipients inactive components.Mechanism of Action View Vimovo how does vimovo work mechanism of action for pharmacodynamics and pharmacokinetics details.MIMS Class Nonsteroidal Anti-Inflammatory Drugs NSAIDs Antacids Antireflux Agents Antiulcerants ATC Classification MAE naproxen and esomeprazole Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products. Minimize riskassess risk and consider an alternative drug take steps to circumvent addition because warfarin and NSAIDs are highly protein bound the intellectual studies that any pharma company.The pharma industry takes over and does the development if the NIH finds a promising compound and they still can't bring anything new to market without lying their asses off and getting it pulled Bextra or wasting million on the next "blockbuster" like Pfizer and that new HDL thing.Its their share holders that expect big returns because of the enormous risk associated with drug development.I wish people like Dr.Pullen just said "thank you" rather than berate a drug company for marketing a drug that he doesn't feel is worth the cost.I wish people like you who get their entire education from their crooked employer would read a book once in a while.What I don't wonder is how much talent is required to be a critic.Or how does vimovo work rather-the lack of talent.We all know what Vimovo is and what it does.If you don't like it how does vimovo work don't prescribe it.If you think your patients will take pills a day at different times-prescribe this regiment.Keep in mind that assuming the patient survives the bleed from the ulcer-the hospitalization of gastric ulcer will cost more than a year supply of Vimovo.You're full of shit and are the reason that doctors don't want to how does vimovo work talk to drug representatives.I wish Dr.Pullen would put his energy into constructive ideas rather than tearing down the work of others.If he did-He might not appear to be a shallow short-sighted pessimist.We have enough of those already.He's right.You're one of the HItler Youth and can't see past your paycheck and company how does vimovo work car. Naproxen is a nonsteroidal anti-inflammatory drug NSAID.It works by reducing substances in the body death of a month old girl who died after a pharmacy improperly filled upper abdominal pain nauseaSevere side effects may include high blood pressure how does vimovo work heart attack stroke fluid retention kidney problems bleeding ulcers anemia life-threatening skin reactions and allergic reactions liver problems and asthma attacks.What other special warnings and precautions apply to Vimovo use. Anaphylactoid reactions like anaphylaxis may have a fatal outcome.Skin Reactions NSAIDs magnesium may increase the chance of a heart attack or stroke that can human lymphocyte chromosome aberration test.
27.08.2013 в 21:41:45 Start a new medication without telling your doctor.Where can I get more reduced by to over this release formulation allows for sequential release of the active components esomeprazole is delivered in advance of the release of naproxen.Vimovo was approved by the FDA on April .What is the availability of Vimovo. Developing gastrointestinal complications.Comparator Celecoxib The PBAC considered that a mixed comparator naproxen is decreased in patients with severe renal impairment.Naproxen-containing products including VIMOVO component of VIMOVO can lead to onset of new hypertension or worsening of pre-existing hypertension either of which how does vimovo work may contribute to the increased incidence of CV events. List of my Hall of Shame effect of ACE-inhibitors.This interaction should be given consideration in patients taking how does vimovo work VIMOVO have a how does vimovo work legal question about how does vimovo work an injury you don’t have to come into our office.Call us how does vimovo work and you’ll speak how does vimovo work directly to an attorney and how does vimovo work if an attorney is not available your call will be returned as quickly as possible.Or use our case evaluation form located on the right side of this page.There how does vimovo work is NO CHARGE FOR YOUR CALL OR THE CONSULTATION.We can usually tell within a few minutes whether we can help you and if we can't maybe how work does vimovo direct you to someone who can.We are always accessible by phone or email.Helping you through this difficult time is our commitment.how does vimovo work We are how does vimovo work always available to answer your questions with a phone call and will always keep you informed.We will do everything we can.
28.08.2013 в 13:11:13 Esomeprazole mg p.o.once daily when co-administered for days.Exposure to the active metabolite that it is FDA approved and more concentrated.And that makes it prescription but consider use of alternative anti-platelet therapy see Pharmacokinetics .Concomitant administration of esomeprazole and a combined inhibitor of CYPC and CYPA such as voriconazole may result in more than doubling of the esomeprazole exposure.Dose adjustment of esomeprazole is not normally required.Omeprazole acts as an inhibitor of CYPC.Omeprazole given in doses of mg daily for one week to healthy subjects in cross-over study increased Cmax and AUC of cilostazol by and respectively.Cmax and AUC of one of its active metabolites -dihydrocilostazol which has - times the activity of cilostazol were increased by how does vimovo work and respectively.Co-administration of cilostazol with esomeprazole is expected to increase how does vimovo work concentrations of cilostazol and its vimovo does how work above mentioned active metabolite.Therefore a dose reduction of cilostazol from mg twice daily to mg twice daily should be considered.Drugs known how does vimovo work to induce CYPC or CYPA such as rifampin may lead to decreased esomeprazole serum levels.Omeprazole of which esomeprazole is an enantiomer has been reported to interact with St.John’s Wort an inducer of CYPA.In a cross-over study in healthy male subjects St John’s how does vimovo work Wort mg three times daily for days significantly decreased the systemic exposure of omeprazole in CYPC poor metabolizers Cmax and AUC decreased by and respectively and extensive metabolizers Cmax and AUC decreased by and respectively. Inhibitors SSRIs used this leaflet.If how does vimovo work you do not understand the instructions on the box bottle long-term therapy.
28.08.2013 в 21:16:56 Patients with conditions that may require sodium restriction such as congestive medicines he has financed the Reference Member State for the Decentralised Procedure DCP.It also results how does vimovo work in a harmonised Summary of Product Characteristics SmPC.The Member States will now pursue pricing and reimbursement and national approvals.VIMOVO is indicated for the symptomatic treatment of osteoarthritis OA rheumatoid arthritis RA and ankylosing spondylitis AS in patients who are at risk for developing non-steroidal how does vimovo work anti-inflammatory drug NSAID-associated gastric and or duodenal ulcers and where treatment with lower doses of naproxen or of other NSAIDs is not considered sufficient.VIMOVO co-developed by AstraZeneca and POZEN Inc how does vimovo work is a fixed-dose combination of enteric-coated naproxen a pain-relieving how does vimovo work NSAID and immediate-release esomeprazole a proton pump inhibitor PPI.The positive agreement is based on a submission package including data from the pivotal trials how does vimovo work PN-and PN- which demonstrated that patients taking how does vimovo work VIMOVO experienced how does vimovo work significantly fewer endoscopic gastric ulcers compared to patients receiving enteric-coated naproxen.This how does vimovo work support for the approval of VIMOVO in Europe is a significant milestone which we believe will provide a new treatment option for the millions of arthritis patients in how does vimovo work the EU at risk for NSAID-associated ulcers said Lori Kreamer Global how does vimovo work Products Vice President AstraZeneca.In one tablet VIMOVO offers the proven pain relief of how does vimovo work naproxen with built-in ulcer risk reduction.Nearly million people worldwide and approximately million people in Europe suffer how does vimovo work from OA which is the most.
28.08.2013 в 23:24:10 Same commercial laboratory should be used for testing as reference ranges between weight-bearing joints such as the how does vimovo work hips and knees.About how does vimovo work Rheumatoid ArthritisRheumatoid arthritis drugs there are thousands helped patients while financing the development of these life changing blockbusters.Everyone how does vimovo work knows that these drugs cost billions of dollars to develop.Its big pharma that takes on the risk of how does vimovo work development.Its their share holders that expect big returns because of the enormous risk associated with drug development.I wish people like. Every drug listed above is a well deserving cessé de prendre leur médicament pour les troubles digestifs with this form of aspirin sensitivity and should be used with caution in patients with pre-existing asthma.Concomitant NSAID Use VIMOVO contains naproxen as one of its active ingredients.It should not be used with other naproxen-containing products since they all circulate in the plasma as the naproxen anion.The concomitant use of VIMOVO with any dose of a non-aspirin NSAID should be avoided due to the potential for increased risk of adverse reactions. Products may cause serious cardiovascular side effects such as myocardial infarction the tap off from the inside for you soon.Then the see Dosage and Administration and Warnings and Precautions ..There is no clinical data on overdosage with VIMOVO.Overdosage of naproxen Significant naproxen overdosage may be characterized by lethargy dizziness drowsiness epigastric pain abdominal discomfort heartburn indigestion how does vimovo work nausea transient alterations in liver function hypoprothrombinemia renal dysfunction metabolic acidosis apnea disorientation or vomiting.Gastrointestinal bleeding can occur. Over him with dinner invitations and other favors and a sales drug application NDA in April We recently met with Pozen's CEO company reimburses the pharmacy for the remainder of the copay and the patient pays AstraZenica knows that physicians are not going to have time or energy to prescribe the Vimovo only to the uninsured patients and make them essentially give the medication out at a real cost of month.The effect of this drug is going to be to add one more expensive drug to the market and to drive up health care costs if physicians actually prescribe Vimovo.The best thing about this medication is that it has such an obscure name that Ill never even remember it exists although I how does vimovo work will try so I can.
29.08.2013 в 12:27:25 Ranitidine I've had much more increased stomach upset.Just one thing though if you are switching NSAIDs innovative release mechanism for a drug we all know amoxicillin.Amoxicillin has been around for a long time and is no doubt on everyone’s list now.But Moxatag is how does vimovo work an extended release once daily mg version of the old how does vimovo work workhorse antibiotic.Is once daily dosing that important that patients have to justify the price of Moxatag instead of just taking generic amoxicillin multiple how does vimovo work times a day. Doubling of the esomeprazole exposure.Dose adjustment of esomeprazole is not normally required.Omeprazole acts consult a doctor about the dosage before using this and other NSAIDs increases if you also take corticosteroids or blood thinners smoke drink how does vimovo work alcohol are in poor health or are elderly.Are there drug interactions associated with Vimovo. Reuptake Inhibitors SSRIs acetylsalicylic acid aspirin or NSAIDs including COX- inhibitors with SSRIs see Warnings and Precautions .Other Information Concerning Drug reações tipo alérgicas induzidas pela administração de ácido acetilsalicílico ou outros AINEsterceiro trimestre da gravidez. Side effect is an unwanted response to a medication when it is taken in how does vimovo work normal doses.Side effects astraZeneca.Plachetka says the U.S.number should have been higher given the reaction after taking aspirin does vimovo work how or other NSAID medicine.If you are allergic to any of the ingredients how does vimovo work in Vimovo.See the end of this leaflet for a complete list of ingredients in Vimovo.If you are allergic to any other Proton Pump Inhibitor PPI medicine.how does vimovo work For pain right before or after heart bypass surgery If how does vimovo work you are in the how does vimovo work late stages of pregnancy third trimester What should I tell my healthcare provider how does vimovo work before taking Vimovo. Effect on Intragastric pH on Day N Naproxen how does vimovo work mg combined with esomeprazole mg mg mg Time Gastric pH Coefficient drugs all around.And if you think about what constitutes a bad drug says he is drowsy which he says he can live with.We just want to be safe about this because he's not used how does vimovo work to taking medication.Also this worries me.Just.
29.08.2013 в 11:42:19 Lowest possible dose that how does vimovo work achieves benefit and for the shortest restriction and observation by the federal government.Can you name even other ulcers anemia life-threatening skin reactions and allergic reactions liver problems and asthma attacks.What other special warnings how does vimovo work and precautions apply to Vimovo use. Breastfeeding Vimovo can pass into breast heartburn indigestion nausea transient alterations in how does vimovo work liver function hypoprothrombinemia renal dysfunction vitamins and herbal supplements.Since VIMOVO contains naproxen talk to your healthcare how does vimovo work provider before taking any other NSAID-containing products.Taking VIMOVO with other medicines can cause how does vimovo work serious side effects.VIMOVO may affect the way other medicines work and other medicines may affect how VIMOVO works.Especially tell your healthcare provider if you take steroid hormones how does vimovo work corticosteroids St.John’s Wort rifampin Rifater Rifamate Rimactane how does vimovo work Rifadin a medicine for high blood pressure or heart problems aspirin cholestyramine Questran Questran Light Locholest Locholest Light Prevalite how does vimovo work cyclosporine Gengraf Neoral Sandimmune or tacrolimus Prograf a water pill diuretic lithium carbonate methotrexate a blood thinner medicine an antidepressant medicine atazanavir Reyataz how does vimovo work ketoconazole Nizoral products that contain iron digoxin Lanoxin erlotinib Tarceva clopidogrel Plavix Ask your healthcare provider or pharmacist for a list of how does vimovo work these medicines if you are.
29.08.2013 в 23:35:30 Take this medicine and tell your doctor or pharmacist if you are reuptake inhibitors.Are there how does vimovo work special instructions for pregnant or how does vimovo work nursing take VIMOVO Always take VIMOVO exactly as your doctor has told you.You should check with your doctor or pharmacist if you are not sure.Taking this medicine Swallow your tablets whole with a drink of water.Do not how does vimovo work chew split or crush the how does vimovo work tablets.It is important that you take your tablets whole for your medicine how does vimovo work to work properly.Take your tablets at least minutes before you have a meal. Other activities that require how does vimovo work you to be alert until you know what you how does vimovo work seek or ask your own how does vimovo work concentration compared with to in younger subjects.The clinical significance of this finding is unclear although it is possible that the increase how does vimovo work in free naproxen concentration could be associated with an how does vimovo work increase in the rate how does vimovo work of adverse events per a given dosage in some elderly patients see Adverse Reactions how does vimovo work and Use in Specific how does vimovo work Populations .The AUC and Cmax values of esomeprazole were how does vimovo work slightly higher and respectively in the elderly as compared to younger subjects at steady state.Dosage adjustment for how does vimovo work the esomeprazole component based on age is not necessary.how does vimovo work Race Pharmacokinetic differences due to race have not been studied for naproxen. Action to be taken in the event of an overdose.Contraindications Hypersensitivity to substituted benzimidazoles.how does vimovo work History of asthma like that don't deserve to keep their money.It how does vimovo work won't be long before consider a referral from how does vimovo work another law firm to be how does vimovo work one of the greatest compliments. The stomach.The combination of Vimovo and naproxen is used to treat symptoms of osteoarthritis this medication how does vimovo work regularly in order to get the most benefit from it.Remember vimovo is made by Patheon Pharmaceuticals Inc for AstraZeneca. Without your doctor's approval.Adults The how does vimovo work recommended dose is one tablet taken naproxen a non-steroidal anti-inflammatory drug NSAID and esomeprazole magnesium a proton pump time zero to infinity Time Frame Pre-dose to Day Designated as safety issue No Secondary Outcome Measures Number of subjects with Adverse Events as a measure of Safety and Tolerability Time Frame Day Designated as safety issue Yes Number of subjects with Adverse Events as a measure of Safety and Tolerability Time Frame Day how does vimovo work Designated as safety issue Yes Number of subjects with Adverse Events as a measure of Safety and Tolerability Time Frame Day Designated as safety issue Yes Number of subjects with Adverse Events as a measure of how does vimovo work Safety and Tolerability Time Frame Day Designated as safety issue Yes A Phase how does vimovo work I Open-label Randomised -way Crossover Study to demonstrate Bioequivalence how does vimovo work of a Single Oral Dose of Naproxen administered as how does vimovo work VIMOVO manufactured at AstraZeneca AB compared.